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KMID : 1188320090030040285
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Gut and Liver
2009 Volume.3 No. 4 p.285 ~ p.291
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Prediction of Complete Necrosis of Hepatocellular Carcinoma Treated with Transarterial Chemoembolization Prior to Liver Transplantation
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Kim Sue-Jin
Choi Moon-Seok
Kang Ja-Young
Choi Dong-Il
Park Cheol-Keun
Gwak Geum-Youn
Lee Joon-Hyoek
Koh Kwang-Cheol
Paik Seung-Woon
Yoo Byung-Chul
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Abstract
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Backgrounds/Aims: Compact lipiodol uptake without enhancement on multiphasic helical computed tomography (CT) has been suggested as a radiologic response criterion in hepatocellular carcinoma (HCC) patients treated with transarterial chemoembolization (TACE) and subsequent partial hepatectomy. However, its usefulness has not been fully investigated in the explanted liver.
Methods: Between 1998 and 2007, 81 patients with HCC underwent 1-9 sessions of TACE followed by liver transplantation (LT). Thirty-nine tumors in 29 patients showed a radiologic response on CT performed prior to LT. The radiologic response criteria and the duration of the response were evaluated to predict total necrosis in the explanted liver.
Results: Among the 39 tumors, 34 nodules (87.2%) exhibited total pathological necrosis. While 13 out of 16 tumors (81.3%) with a radiologic response for 6 months or less were completely necrotic, 21 out of 23 tumors (91.3%) with a radiologic response of longer than 6 months showed total necrosis.
Conslusions: Our results suggested that the radiologic response criteria based on serial CT images might be useful for predicting total necrosis of TACE-pretreated HCC in LT.
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KEYWORD
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Explanted liver, Pathology, Computed tomography, Radiologic response
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